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I Chuan Hsueh Pao 1996;23(3):174-82

[Population genetics of short tandem repeat locus HUMTH01].

Hou Y, Gou Q, Wu M

The distributions of genotypes and allele frequencies for the short tandem repeat locus HUMTH01 in Chinese and German populations were studied by amplified fragment length polymorphism analysis. The PCR amplification products with different primers were compared by coelectrophoresis and the population data from different laboratories were evaluated. Based on the allele frequencies of HUMTH01, the genetic distances among 25 populations were computed and a phylogenetic tree was constructed accordingly. Some new implications for population genetics were obtained from this phylogenetic tree.

PMID: 8950847, UI: 97108344 

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I Chuan Hsueh Pao 1995;22(4):245-51

[Amplified fragment length polymorphism of the VNTR locus COL2A1 in Chinese population].

Hou Y, Gou Q, Wu M

The amplifiable VNTR polymorphic system COL2A1 has been investigated in a Chinese Han population (n = 120) by the polymerase chain reaction (PCR) and PAGE horizontal electrophoresis followed by silver stain. In order to accurately identify COL2A1 alleles, a number of human allele ladders prepared by mixing DNAs extracted from different individuals of known COL2A1 genotypes were used. A total of 14 different alleles in 23 genotypes were observed in this Chinese Han population. Among them, four were new alleles disclosed in the present study. The results imply that COL2A1 locus may be served as a genetic marker in forensic haemogenetics as well as in anthropogenetics.

PMID: 8703516, UI: 96307986 

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I Chuan Hsueh Pao 1994;21(5):337-41

[The distribution of gene frequencies of immunoglobulin allotype G2m(23) factor in Chinese populations].

Hou Y, Gou Q, Wu M

The distribution of G2m(23) gene frequencies in eight Chinese populations, which cover three ethnic groups, was studied by enzyme linked immunosorbent assay inhibition test. According to the results of multiple linear regression and multiple liner correlation there exists a cline of G2m(23) gene frequencies along with the height and latitude in China. In addition, an equation of multiple linear regression which can be used to expect the G2m(23) gene frequencies in some Chinese populations was established. Some possible reasons for this cline were also discussed.

PMID: 7848661, UI: 95151340 

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I Chuan Hsueh Pao 1993;20(5):399-403

[Genetic polymorphism of inter-alpha-trypsin-inhibitor (ITI) in a Han population in China].

Hou Y, Gou Q, Wu M

Phenotypes of inter-alpha-trypsin-inhibitor (ITI) have been determined by isoelectric focusing on the polyacrylamide gel followed by immunofixation. The phenotype frequencies of ITI in the Han population in Chengdu, China were investigated using this method. In addition, family studies have been conducted in 21 families. The results showed that the ITI was polymorphic in the Han population in Chengdu. The allele frequencies were as follows: ITI*1 = 0.5763, ITI*2 = 0.4107, ITI*3 = 0.0130. It was obvious that the ITI is a new and promising genetic marker which can be used in the field of forensic haematogenetics.

PMID: 7512818, UI: 94213771 

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