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Exp Clin Immunogenet 1996;13(2):112-6

A study of polymorphism of antithrombin III at the level of both protein and DNA in a Chinese population.

Gou Q, Hou Y, Zhang Y, Wu M

Department of Forensic Biology, West China University of Medical Sciences, Chengdu, PR China.

The protein and DNA polymorphisms of human antithrombin III (ATIII) were studied by isoelectric focusing (IEF) and PCR techniques in a Chinese population sample (n = 51). Products of two alleles within the coding region of the ATIII locus were observed by IEF. The allele frequencies were: ATIII*1 = 0.9608, ATIII*2 = 0.0392. The PCR analysis of the fragment length polymorphism (FLP) for the ATIII 5' locus disclosed two alleles. Their frequencies were: ATIII5'*1 = 0.4118, ATIII 5'*2 = 0.5882. An association analysis between these two ATIII polymorphisms revealed the incompatibility between the ATIII 5'FLP and the ATIII IEF variants, indicating that the ATIII 5' FLP is not responsible for ATIII variants.

PMID: 9063703, UI: 97217742 

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